	   SnapGene      !GTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCACTAGTCCAGTGTGGTGGAATTCgccaccatggcttctggagccgattcaaaaggtgatgacctatcaacagccattctcaaacagaagaaccgtcccaatcggttaattgttgatgaagccatcaatgaggacaacagtgtggtgtccttgtcccagcccaagatggatgaattgcagttgttccgaggtgacacagtgttgctgaaaggaaagaagagacgagaagctgtttgcatcgtcctttctgatgatacttgttctgatgagaagattcggatgaatagagttgttcggaataaccttcgtgtacgcctaggggatgtcatcagcatccagccatgccctgatgtgaagtacggcaaacgtatccatgtgctgcccattgatgacacagtggaaggcattactggtaatctcttcgaggtataccttaagccgtacttcctggaagcgtatcgacccatccggaaaggagacatttttcttgtccgtggtgggatgcgtgctgtggagttcaaagtggtggaaacagatcctagcccttattgcattgttgctccagacacagtgatccactgcgaaggggagcctatcaaacgagaggatgaggaagagtccttgaatgaagtagggtatgatgacattggtggctgcaggaagcagctagctcagataaaggagatggtggaactgcccctgagacatcctgccctctttaaggcaattggtgtgaagcctcctagaggaatcctgctttacggacctcctggaacaggaaagaccctgattgctcgagctgtagcaaatgagactggagccttcttcttcttgatcaatggtcctgagatcatgagcaaattggctggtgagtctgagagcaaccttcgtaaagcctttgaggaggctgagaagaatgctcctgccatcatcttcattgatgagctagatgccatcgctcccaaaagagagaaaactcatggcgaggtggagcggcgcattgtatcacagttgttgaccctcatggatggcctaaagcagagggcacatgtgattgttatggcagcaaccaacagacccaacagcattgacccagctctacggcgatttggtcgctttgacagggaggtagatattggaattcctgatgctacaggacgcttagagattcttcagatccataccaagaacatgaagctggcagatgatgtggacctggaacaggtagccaatgagactcacgggcatgtgggtgctgacttagcagccctgtgctcagaggctgctctgcaagccatccgcaagaagatggatctcattgacctagaggatgagaccattgatgccgaggtcatgaactctctagcagttactatggatgacttccggtgggccttgagccagagtaacccatcagcactgcgggaaaccgtggtagaggtgccacaggtaacctgggaagacatcgggggcctagaggatgtcaaacgtgagctacaggagctggtccagtatcctgtggagcacccagacaaattcctgaagtttggcatgacaccttccaagggagttctgttctatggacctcctggctgtgggaaaactttgttggccaaagccattgctaatgaatgccaggccaacttcatctccatcaagggtcctgagctgctcaccatgtggtttggggagtctgaggccaatgtcagagaaatctttgacaaggcccgccaagctgccccctgtgtgctattctttgatgagctggattcgattgccaaggctcgtggaggtaacattggagatggtggtggggctgctgaccgagtcatcaaccagatcctgacagaaatggatggcatgtccacaaaaaaaaatgtgttcatcattggcgctaccaaccggcctgacatcattgatcctgccatcctcagacctggccgtcttgatcagctcatctacatcccacttcctgatgagaagtcccgtgttgccatcctcaaggctaacctgcgcaagtccccagttgccaaggatgtggacttggagttcctggctaaaatgactaatggcttctctggagctgacctgacagagatttgccagcgtgcttgcaagctggccatccgtgaatccatcgagagtgagattaggcgagaacgagagaggcagacaaacccatcagccatggaggtagaagaggatgatccagtgcctgagatccgtcgagatcactttgaagaagccatgcgctttgcgcgccgttctgtcagtgacaatgacattcggaagtatgagatgtttgcccagacccttcagcagagtcggggctttggcagcttcagattcccttcagggaaccagggtggagctggccccagtcagggcagtggaggcggcacaggtggcagtgtatacacagaagacaatgatgatgacctgtatggcCTCGAGGAACAAAAACTAATATCAGAGGAAGATTTGGAACAGAAACTAATCAGTGAAGAAGATTTAGAGCAAAAGTTAATTTCCGAGGAGGACTTATAGTGAGGGCCCGATATCTCGACAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTATTCTTAACTATGTTGCTCCTTTTACGCTATGTGGATACGCTGCTTTAATGCCTTTGTATCATGCTATTGCTTCCCGTATGGCTTTCATTTTCTCCTCCTTGTATAAATCCTGGTTGCTGTCTCTTTATGAGGAGTTGTGGCCCGTTGTCAGGCAACGTGGCGTGGTGTGCACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCATTGCCACCACCTGTCAGCTCCTTTCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGGCGGAACTCATCGCCGCCTGCCTTGCCCGCTGCTGGACAGGGGCTCGGCTGTTGGGCACTGACAATTCCGTGGTGTTGTCGGGGAAGCTGACGTCCTTTCCATGGCTGCTCGCCTGTGTTGCCACCTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCCTCAATCCAGCGGACCTTCCTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCTTCGCCTTCGCCCTCAGACGAGTCGGATCTCCCTTTGGGCCGCCTCCCCGCCTGGAAACGGGGGAGGCTAACTGAAACACGGAAGGAGACAATACCGGAAGGAACCCGCGCTATGACGGCAATAAAAAGACAGAATAAAACGCACGGGTGTTGGGTCGTTTGTTCATAAACGCGGGGTTCGGTCCCAGGGCTGGCACTCTGTCGATACCCCACCGAGACCCCATTGGGGCCAATACGCCCGCGTTTCTTCCTTTTCCCCACCCCACCCCCCAAGTTCGGGTGAAGGCCCAGGGCTCGCAGCCAACGTCGGGGCGGCAGGCCCTGCCATAGCAGATCTGCGCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGCATCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGGGGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCAATGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGTCGACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGG  H)   !   &      $   &   3   ,      +            (   '   6   )   -   (      &   7   !         0      #   )      "      %   7      "            $      '         )               "         '   .   $   #      >       *   7   !   6   %   2      (      -   %   #   %            $         *   ,      $   "      (   '   @           +                         +   7                     0               /   $   *               !                                        9   -   7   +   !   ,   6   *      &            2   3                                    $               *   *   #   ,               )      ,   )   '      ,   2                 (   (   )      '      '       #   &   0   '   "         &   "                              +   4   (   +   $   /   !   *   %       &      (   4               1   1   $   5               #      3   /      ,      )            2   /   &   2       ;      -         4   #   0        ! Y ááì^_9	·	¹ž/ÿ q¥ø&'Ë¤õ�`�!?¬.â0 & á xâ bâ•í2SÀß:	Ö¾0iœ¥>|�•"­/,×vá®b  Z ÷ …	ÞU\rÙ(QÙø£óž@ãˆö1 $  ÈNµ}`¸	ºó™Ÿè¦æùÌ¾öR‘ža:ðÂtÛ7¶& t û cÊ}£îKÓ)€~“Á;	Ÿ	«	 
Â
0âú‰WG!?§/®Øc ¾ 3 ´uÊ1dx²5TŽ¦¬d3Tà’×8MVá1ù$(oçþF}3É÷)€:_å-bó3w—¯¿, ÎãžJ¸ã– ¤ÁÓi‰	à	”
<µõ^Ü�¦Tfl‡£/H™Ü#0ëÂ#â/	 ]  â y!&�&^Ðš
Œ¿j’].‚Qü–Ç6+ ø ¬_±Ù2`’¯+Q|}†B±	´	ßx&VÚRWùA¤ÆôA¶\•¼˜‰ Œ MR’>L
j<K¢	3Ñ)T O¥¿äúAn�Ï ´Õ
4	DšsZÚ2µ“þŸìZŸ¶˜äX÷2  [ fëùè„	]x†:ëëbäkH&x Á (  ÉOVx…ñ
ýsÞú@N÷S’á„”¬ù03à³Ãùx¹Ø5ôÀÖ ·' ]‡º5u¶ÈR~¯ä	Áô 	k 9„ýÍï^¿4Ÿ×}Š´^›ê 6 œ {Ã.,£Ù˜	¹	v
©
¹
»$F­€ç²
RÍ*¬´Ïè<E‡Óä÷b}ï;ñó†u)ÜÔï )   “ T¨aí	D	_	
5
ë
è0š_ƒ¢µé§à­êð$›IÐë¡OZlè8C- d$^JþŒ'*{³¡Ñæ@gB	 	1:û6K‡Š—Uèî"jª2—±´øˆÙ¿ ( }‚®~üL`Íñ0jl/t×O	¬	\
Ñ
þ
LVšš`¨ÂË¯±?d  u ü Á¤
	Â<	Ä	¡
 ´X×H‡0K´ia÷›ÇÈ & t˜Ëï¿ÔùQ�v”$	„	Ã
ãuÀ @#X*‘Ú$OüG—ô<Œ Ó 7 ùz„°2eé6�2L»U¨^
7ad“Nil2%Ýbw~•4U'*æ.3RËD4Cx9˜é!! qvy³­n4áQ	Û	\ÅúÿGÄÊ¦è �;¼cºø#À  F  µN¼Ë�5 	õ
HÚè"½6øœ(³°È ! üU§FeîØ9Wâ)p~&p?`�ôù0  ¯ÜGKœ«¹äÿ&—"NNW¥VY¾Ôàj�	®	á	Y
•
=œ!$g„Ø×0I¯‡K’  % ÏŸEŸö�+1ÑÉÒùã
 # 7 äÐ³·¿ô1Š	�	Ó
ËQo¶É_à“ž§ÅzˆÝcÍÓì¯	) Ÿ¹ßäó:ÂÑ	 
>
@NXÝUZm¤òCLš$xÃÎÖ$0™î .0Ae^ f n  ¹ Å î AJûE'‹8kÔ6/A/OkR‘„·”§éT Z " 1 'c)€×%bX�´Z	×	
Í
…‹§DbÈ	ÃÄ7pºø  > ã zÚ"ÏvŒ›
²
�ÍÀ^Ñºƒå—ÝÈÉ¹”| %   « pßož±›Öä_ËÙÑÀ	0
È
¨'“œi÷¥ý?«¯Î“Ãô 7 ù Ì`¯²0/�“¡­°,R~\ƒ:‘Ý2	�	²	µ	˜
àøó]qv$UX[åüD¥CÇé÷�·3–ñFº ­ÚaÝ½tó
ƒg•ÃÛg£þME†’™Š" #Y­.3iÖ}s	ù	f
y‚'RWSìîúBáõü4]yÄ½J¸· ¹  œ‡šCu	Þ
F{æe˜KB‹ñ{ïYK Í  SÄk=4;L_ÿo�Æ…Ê  M � Õ N2? L£	ã6e¦Àåc�<ƒN$ È þ %•Mj�Š–,Ò 9*eFÈU´Ä½Pû;BYÐº ¦   3j‹¾[“Ø[)�„ ' . VkÃÎ•˜êh
Œ
àEZd›)TYDníšdrk²p¢¥
2@É<Å»    C ~ Ãû}[¶ô[Yt�ùLYø�   µÖ‚Š«5	Ÿ„a¶3qýG õ·{Û™¡G—Ë‚) c w Ì Y¦Æ¦ÄÉû	£
zetÕ«ÛPe¶”ãÿVu‰ 2ïýXfŠ§ˆåG3  /úS¶,Ù^Œõ@ Ë|ˆìcÁÈW y Â  \ ¼ ñ D›þçémK	Æ	ïg°¼ð6~ìq¬ì°¿5w©Ù íg>	9
KÁ‡;À¯ålžeþ ¨5;“Œì…	é	a
…
;n{yJK‹¤¶I'" ²ÓPƒ0þßg� ³oû>LO:zßâú1“ª´÷þ“¾   çyòØ“!•­4¤µúºö—ÿõÁ!¸Ñ   , | ÊW€hšÜ
t¿´eTáb»pyÙ1×€'  †

lsue/4AJ`z‚ðø8]g…‡kg¨Äåó6šHµ>›ì8 Ï . ˆ»qS29°ÉS’ø±Âõ
ìþb[_å�ò+5_ hN7ØÛñ©¬·@G_ö$ HvÇûÌ¬·�
ä
wlŽ:!:i‚1ÚgIT~¥ô!N�Žœ¦Õ ë # ^Žî6Éˆß°å	¡CÎ&*nrvèZ‰mm„’-”™µgmì˜ ÿ  ·+–}Q…ðŒÀ%}‹b[: >  � n‡ž/Á-O‰¤�Ú&	i	†	º	½	Å
è
åûHˆûþ5G§�ÂÎÐéFbˆÔåð$<,ò‘âôuIqv—OŒñ9Å   ¡|<S xúw	
w
ª
îv1m­µ=‹øÖQ*{®à *  ŽÄ–ý*º
à
n¼Åþ%Ç‘³è+BŸî¶Ô,CMòQÜtÎ8}ÝÕŠ³ ð !7 všÑ@»9`êœ§)	™	C
ã´	J®è ˆÁS8Óg¹c~]iÆÖç‡ªéõCjJrì
ÄßÌ� ¬ ! ÍXã6
wëªê¯ëñœÛÞš¿7mºÑìZÜ	&m09sD£• 6 ! Ú .»ëõ?Zn°Eîô			E	d	“	&
k
�
Ø
ì
+g¦ÙW¨ïv¦ JiyÃ�¢P[ÑÞU,Œ¨|îM ¢ % ˜ YÜñ„Ö!©b
H1îòN£¶Çíõ®ôú%²r|ß;DœµZ2 j ” ¤ ² 7Ue=AúÀZj•`	l	£é›`÷„Í°á6|„&:�œ¥±»Æúÿ�º9pŒ�éÒ à àë´¿	ÕÝò˜~å%Ø
›÷ô€_-Ú6­µõ/ ( %t|ÿ4J�«(%Òh}“
;7Lˆ‹V'ek-¢G˜9^Æê5Á".– eØ_K|	içAJ¡	2@’ëµNaùÀ -  U4t+¢	C	^	—	u

üjß 	Q]éï#)«3|ƒ²NYk…×‰³óšé î % s|Àý	‹ik². Ð?fN	Ð
ÿ
9³Jtç_©W)Ù°³óh~# øûyƒ¯14mEºP	Ú	]
6c[kGa
Ã'>2¹ÊB8²ø !% $ F²¸DMòV09U½­	Ð	Ò
MW›ÊPnÈƒÌÐ®Í/È†@e  ~Öa°ÎÕuØWœ/
§ÓC›.aÇÃ "¬-h.¬ÜE‚÷f”åZ—3Lð…îEI·J Ì  L Ô ý 2iŠ½‰•dÇ:Xb€„;œƒ ¥ É $ B b v UÂ¥”úªÃ‹
¢
|YÔóµˆ1™WXjFs±‡�–ø?ÈFœ  šì§
=	Å	`
„
µîØI5J}Š{¯µd¨ Òg‚Û
�=Idy�ï7y j’´ý0õ’–= * pí8Æú¯ËÞ‘÷*•°v%9Zm�$Yflƒ,HS˜Úð¨« aõl�ëÔ , u�™†;?ÀRéNw€%	h	…	B
Ä
ç
Ää³4ÀÁ7Aa+PÕÛñP�èpqzÞß  i Ìê@ôW¿ðƒÕ m”¯ó*fî6l%:ŽÝT+/¡ $ ×s3{êIs¾	]	–	t
’
&Þš‚êMXj4À!5ò-™¬´è í " úEx{±¯3hD¹¼V8bOjmÇB^‚V(=ÏÂgÉÌ…! !1ë«©_
ƒ
”{ÓIc–Æ2®EWDƒ:>§I ( oŒ…Vf7‚®M®òg	æ
e3H¿$l6x5³e‚+9ç/oS§yê  Þ ' ÖrwzªH®g­ñzÆA #Hk5Åéd�18<LWiÎf¿ V«H @ *Õfoâï	ð	ñ	ò	ó	ô	­
=>y¼?@Lýþÿ¹º»ÍÎ34ËKVgh ¡de»¼½¾ù>? $�‘ž¨©ª! " G ×   � P+JÉý R	Ü	õ	®
½=Æ¼ÏÌ§`t}¢9@LŸÁ# + Ø   	†ô´øp5pã!?]ûMk j¨‚½€„úe&%’' + � Â ô GQÅ,K!Êè6qý	H	Ý	ö	¯
¶
ˆ½é#ÜÍ7¨W±H™@Azö Â  I ¿ Ý ½ÌD<I«W¾ai~#“´Üæ±Éà$ ,  S ¶Oxþ¡€¾ÐÛß1yÕu^:lkÙ û  O A�S	ö
bª>ŠÇËùå�)£MQ�ˆ ! ¨ × ùqnüNlòÕ¥4õŸë 4çõ*µ¨ÒÛGf¥	:XqtÊÄ@ç�“( å   … 
7‡Vqïä	@^Úã	k–«'qB©T¨#ûfÌPú&a ýÏÎ"6NÌ	
z
"Ù®�*{<„¾ƒa¾‚º…'£P+ r ‘ õ RvªÆLÁHOév¢¦Æ¿Î¯	Þ	â	·
.."DË…Ñ1ªÄÎ8XéÒV\v 7 Ã HnÝ"L�¬º' #Ë÷OJWrÕì²þ‚	Z
°
>‰˜"%S4¾hx¸$J©æIšB_÷þ !  Ê -å »Z�k0	I	ç	÷	–
�Þñê²¾CýLÃ  ,c°ø˜7Xá	j(gpãÙØÝ‹°*A{zˆ¼¡“  J g Ò Þ Ð¾’
,Xˆjïƒ¯”µó- š  ƒ À mÍF;=Ji˜Ub/2ÌÊ$iä²%  & n p *kE H¿[]á  (  O?÷�¬êÆ ÒÓúÝçÊÐ 0 4 ; ¶ ë >øBP#ÆË(y¸ÿKŠÀáÈÝ÷�	¨	

Ê£Ö¢²{‰Ž!K_¿m«æûü  8 F T _ `—¤8·EÜ2z[–í°;iã  åƒõÔ
Rp�¿+á”Ÿ¨ÆÑÖßNÎv†=
¢î  > Ú  ·Ñî´2¢z	‹	ŽÌÔ`‹à¿°ÞdÔ”Úl¬ ž�l][û
èÈ#nÌ@âWoyúž¤¬Î·/_ / P 'ÂäêõåôB�'	É	ÿ	
?
'YGc«[ÎD\ÁÆo®»æ*›N‚ïO
ò$ �BEÃ	T	G
¢Þ�,tV¥¯M›%¶RDÄ×%R‘šä1fog ‰ ¨ !*  ðtºàe‘;³ŒÒ	!
)
M
n
ï
÷
AO?‹,Ð JÊó	!¡yÏ1«V`Bo   W Š Kß]	›ï{Üý7Sí0P’R'àÕß½[  © €úÕ0MS…É"•ÇöÐì º Æ ï B“üro9lyó©BNl'  U  * Ø 5FÚ(ìùŒOm®2^ÖŽì¸¦5¨G³êÂ! èö+f,¶Ú©’ÓÜ#gH{Ø	Î
YEcÅ%Äè8q±” 5(ž[	í	†;¨ºrË€ÂÉ^r{ž‚) † ã æ ù  2 � l�À�&c¹HY¦	
K
Œ
YAüñ <  d*ØµpuÅ-» ;äWÐ-Î—
l»(t„ræ�mÚÔádt•b ? ¤þ³
A_ÛÒÉ©$/Í † ä {ƒ#ˆ¢]�å	R
œ
\ŽÁrCÊgQûv Û8rwðä‡_w—¬+˜ªUÞüºRŸ'UÌÒ}  ¡ •þ7Á	
!—jþ@¬ÙÈb”‰üÄé6õ  §¾ÏAÚ-	Í	
Ú©=…°Ô†wá(¤| qàÐQŸ`ÌO·Ò1
{
É
(¯¬Z”ò´û¿Ï„\+�P  ¬ óp²œ×å#˜#©‘+’�ÇÌø|¦=¿ƒ»Q]  ö wÇMa”„RÞ8	¶	�ç[¤£¢½�ò9œï>Ás‡9 s ú Í³ÉI0c¢±S¥Ò£]cÀ’Ïˆ	ž	ª	ß	™
Ÿ
Á
/áùU´ô ]øF\næýE †¦2PÈÛ.äò½ - «‘°1=‘®*P{êø;ƒ3	°	³	ÐCw™%VY´ÅYžêã@mŽ—jG»ÎW—w 7 ’ › S\†¹zÂ-w§ÇQ®Øìã	
4
¨
¸
ê
Àç/#^rEƒÌDH†Ò«Ïêø/ßw¸4ÖçÓB]+ #­_Ìðø&/PsÖu#	A	ƒ	[
K™–T¿ÿi�JNF³`‡š°>‹ Ç ! Mp»€Kí§ÿô
`hÄÜ}!%v&çÿ›QCÇè !, 6 ®Û›žªþ%Þ!¶ãM¾Xß€	
=
X
? #*’ÄYy×ÖñKwÕøÿd‘ 6 0 = Ÿ ¸ Ä í @IoÙúDÞb($šã‹Ê³Y	¿	Ö	
±
Ç
Ì
„Š&ÌŠ75h@Ð¹¤>ƒªÜ“èo¸“S ó * ®/ ~¼[‚™�Ü1	r	t	ø	—
Âò\z�QTäëíûCdèöœûýDxz‘¶ ¸   $Z×ÃŒ+8:E³Ã5K^þÅ¹M & Ë Xj‰¥ÅÍ—ÂÈéú	g
žßƒ(SXddâtFôü o¤	K;Äº  .4:æ‹lJ	è	~Jf¯+‹ïëp«?£¿‡�¾4vý  ±™æ/~
krd²\Þafºäöò™Gš½Î  R�È1«ã
| )hqä0‹*ÙçM‘“|¤óMfZþ 2  m�Ð•º8ˆ›¦ù(	v	¼	ß
âýG‡ýIu¦çÒfŠ¸µ#L+tBN|ð­‰ËŒ « ² !3 -dùYi>YâD	k	’	%
j
Ž
×
G¢¥ØñöV©uùÚ™¾þŒ±¹ÂCoŒ´r§{Ñ¢L ”   ß Tß	$×	ö(„M` . ! ¿ŠU-Ï>e5s-Ø1.Ç}  A K a Ó ™¦“äY4|‰˜°†•¶› Ë  h Ñ~¾>Ål�ö<€kÔðïp‘ô n‹UrG™Á‚=„³Ÿ Ý  Ž O…G¬¬
<>KjÅ¸c€07fÍ8=KUd%ÿ&  H N Á @üµ
CaVÞÔVäG]˜€k’jå „ Ö 3Î!M¤	y
ÙÉÔ•ªS3§æ"ËO q É +buÅ Í—-Ýð!R3fâ·åü^Ñ[»u  ' o jlN‘:—GTÅËZ\ : E ÿ =–£Åy	ÓÕŠ±Þ¯� J¾<¡hâåú  $ &ãkôŽ‹F¡+€I?ÉÀVxµº Q «ÍC�UNñ§   ) V ‰ 4’\Ùšîëøx­]ìëQ!&²ßÏÔÞ € kŒ¿"zJ
¹o]
,°û … â  ‚¡:\ý*sžuËÑ ¦”P@

 ‘úÇÓ[vàûè5* …¸�)z ÷­ë7	©	
ž
¿TœæZ£E¢³¡�.îÞÀ?liÍA¼ * / 5 < · ì ?ØùC$â%L™â ÉÞX		
<
_Ë?‘|ð‚²vÔ=Æç ò # 
9W¤ÄŠÌ‹–ÁèÁ
7[e*ccDo>E›¢Ÿn£3üµ , 
 QlŒÇÏ¹ø‘	i
�
Ö
â
q¡áF†¤×õUt/Š[·¸"L`e¹s£³q™¦¬ÊÐý   ` ˜,�rÖãõ3{î ! G „ŠTq~ØFU·ÈÓÝ\—7<Jj‘þž Ü  9 D atÄÄ�Q–ÝáIS¹ŸÌTMZäðù U  ˆ ¥9™ü¸ê\ëP\Z±ußúr4t) 	 ·×	‹$öÿ¬ç6	W	~	Õ
^p ¾SÀ	…åb>�¡.¡¸>ž¢Ó˜Ì  ƒp˜qé PÕâêT•ÇÒÜàOH6ISýsï Û ,  ¶„…è,¿45� ×ØÙÚÛ-OÖþ‡ˆ‰Š|}š›œ�Ú5HŒrÚÛ) æ }æ%—†‚'-¹ÃÉ?·À�“ µ6©Pr×Ïÿw‹öv~Ü!:Û£�xƒÜ? '  ¸µÇÓGŒ	�Ä€ÄÊuÖŽ¬7ªQs±ve¡Ðô6ð)Yg_¤‰#H d Ò§H6	ü	­ÇÒ(fßxŒ‹(¨×ÛiyÝ, Æï˜§‡ÙÜß3ÅÊ{	¼
{Õ.ar¸”¡QŒáÀ• ØuŠ�â3•";ÜmŽ­„2 x Í ç ~ç&Z_
£ºT
¤
ÍƒºÊ @—›»»Á—œ¶Üf·äWEÕ ÷wÊÐÝþæÖ4 @   œ¶È\�·-�Úv×öÉ„«R²Í-õ}Ÿéñ*Z`$`  Hm½�	ü
T4¥�õiAãÑÌ¥IX z  0‘Ô›	_oAž¡Iû‰íïd­¥Â¸ÆÉ0W   Ÿ¹^ûÅéLÅËê�¤­$8tewXfpz¢7ÔàhÏŠÃ ( ëB7ž(L	-
@
(€®ÈÓðHdh±Ññ7íE]+±UŒîƒ”Ü6jó� ( Q ½ ò EÃÿÓåò¨öæn	Ê	r
¬ˆ½y/w\	€¯¬>ÇOð¡Ú+Þ) ] e (œèõCIt Æê	Ç	ý	 

E
)æg­ÏÂà(¬¼çí©ØTxªÎ  Ý�y+	Zr²Çpy�WkØ	œEþ)ÀPz' xÇ™¨©Æ?	¿
|²bs°‰â÷ýWÕNÙŽšÁELæm›å�®…Š � © 	! �hìôËH
"Ãˆvã–ÒÝSŸf' EˆnÚÝàF4U	|	:
ÖN¹Â¹•Ra�<€‹4·È°tØ&pÎ2gpÔ  îðCÄò	½
£/Lß¢‚-uÁ–¦°œ&÷#<SÅ’n)ÿh  # y :[u�´ð
P„»!¼Ý™®¸Ã˜åô
Ë‰ÿ¢zWá+€5 & è èð'¡©ñÓá<†»	ê	ø
BAŒKgKËÖ¥x"€l·¬]aC0 6”`»f‡’¢í;�¤Õ 	Ó	"
*
U
o
¥
å14@¶<o˜¼Š�X¨»FøÑùÐ2J (×' Î <bN
b
†
ÎËÑ|œáðzÂ-˜·ÑLUŒ¡:_Þë%¼çA j p ® "  X à|1]¸½.hþTpØ÷PÊ=Q{œ” ~«+áÖuàa  �·Éwœ‘à‘Û#S.ûö(a2¾ \  ‹ L³ÔQ^	w1…ý9Sµêÿ[¤¾”ã%& 
„ð
ÿÝ‚¡¬´8ü?M±î¬š³Îç;àãö“î2 òø(|¿Õ" —]�Iû¾zåÃ	ý
U5†Ö™í1Á"–†Ê#û–÷ ;öÆÒ  èÙ”To¼5¥»€÷"E   ÏóŽ	žŽßB®bÒ˜Ñí-Jm  ª n¦öNj�ä®¶Í¦Â’ÈÂ¹Y { ÷  ËXÕ�›9sœ	e
Ý
ò
pu#fàB¢JŠð2Ã¹X Ç ”1Zi(â¼d‚  - } �yc`µªCOpUmücîqzÚe‰¦¡Ê1� » ð Cý ’8
R:mzÀô»ŸÊ®ÀÇØV   + { tfŸ¾.n³3K_×9f†£§©o´þë7 Ð  G‡¶€
�PëBau�ñ^ˆgl6¶?œF¥9 — +   _ü)
míúÆú0l‡�žíÓ B\hsÅÍÕáæ©ô
7Hi–I‹ë	Ã8Ä 4 — £ ± Ù 6X<ºÛc	vêíMÆÌìô¯5{ƒ¥®%9�›¤°ºÅóÝùhxYq{¹ÛÞ8‹›ÐY‹í( 3ª$hI|	ÔÜñi}äÿ?P\d‘ó,¡F^{,8]ÅÖé²•ô+ # r÷·ÕC±Ô8TŸ›M	Ï	Ù	.
Ï
¦²ÉIZÒF`æ	Æ&²ò­¸A7÷$ h‰¼«,Tg-Û“ùˆŠ
D�íöeò´zV9Wïr„ícŽHE‚ ¤ / é?ìó:ÊÝè“)A
Ú
)¯Ã²Žícx8Y€î6`kiO�R�ÙÜª•*.Ý`k~!  0êDC­¸½	\	f	•	s
‚
‘
å
Ò¾]�
�²­n¦Èñ¦,ç ì * )IÔó©÷ÈüeoŸðî	 <x»üiÌ"j2_s|§JUŸƒ��§* Ö % R ¾ Ü ó FÄ  wçpG	‡©‰;ª0xÊÛh°?Pyõ"Ûß‡ ú   § 6æ)ÍÑÚ	Ë	
­m�ñsz;ƒÃ½A¤¹Ožê¢`ä & m©À÷öu¡ºI€ë±/	æ	-iC'oÊwÐŠ©Ã)½èBýUy  ! f m ‚ Ñ )>h	‡éî.‚®hòÏ ™ ( 3 ^ µ ê _÷Aí"7‚Ê'J‰àÇÜö§	

�*¢¡D¾M…“Z•ªÙ«í= 4 Ž�Á�éïsdAD\²&Z		È	þ	
(
F
L
m
î
ú
&çÏ"+sŸ®Í[ánÅn­šªã_¶~	n ÞzÛR1¨M�L&ÈF~ÆÿÁ¼ e+Ù‘¸Gì	ÁqzX$�ð;  £ã,Q
[~–†qvsŽlÙ
Óà.QcT ò½—¶,	¨«Y–ÆËñ³
Ø<ˆ*Œ\{O 1 š [yÈ<b¤ÑPbQ‚×‡	3
§
À
é
æ³ÏB˜ÿ\÷‚m¼G…OÚñ›-=vãrÕâ�æ–†1 ž oš©ý^µï.Š¦"	@	¾	Õ	
W
Æ
Ë
J‰6)ÃÏþXÖ uÕ%=�Û’Pçn·¯cR � Æ $ ˆŸÂ˜�ÇÛq	}*I€®PŠ9ãêcªsçÂóú†ûJwœu�:5  å0Xh”=¥ª.'	j	»	$
}
üðüHct¥¨±øÑ)‰½æý´Á�n’ãõ˜FMòLe‹ ª ± 
! @ }¥Þ½=‰TÎõd#'—Ó×0-| «ûx
«
´
B`Ä”©ÓFR!T <¢iâóÿÌx	ÜïÔ2‰°®¶>ŒwäÊª� gt  �‘í!y	
I
wnù	%+ÞÎ¯á # „�8£‰á;
�
á
6ôsbC Z¶ï=·-�DÝ±uhÏ´ ñ  ‡ s‰SÃ+Ž�×R¸žË~Þq3!3 å |$–o—#þæV	}	]o½çÿ&O¸ÂÈ>ä¾Œ’Ÿ´Ôé=SŽ,ÕNu 9ÒÙ4R‹üqwÙ/  ÅÒF^ØÛÞG5	¹	S
»
¬ÆÑq–šºÃÉº–›Dt~Œáó5ÉÏ(^'Ö"hÕ ›¼š	3¤
Ké£ôƒh,d�HÓßèîÅV, ÜñAsŸx�Å*	,
D
q
å‡Ðx.v±'«Vj×«=DTÆíý“S *Í  €  wDmë¨ñó¾
±M¯¸ˆ!Â`öüÔ™ÑÇöKsoÍ(Ó~ Ž ) ï9Ò†¡:aÔ	ä03µÐàï‰T˜­Â9—§º^ˆêø$k»\à*i ­  v
¼«"°<™æü›õ8í
'£½{1tâÔ –Î\äÂ	…�˜ÞìÀn�»a­Á ‘:,ÅD l ö  ÿYŽ87
d
ñ
Qxb"ºßÉcˆ¿�2 z – ¢ ° W;µb	ìùž½ëó-²k†Žš£¯¹Äò�ÜÒÿA[ÚÝrÌnŠ	•ŠýXEê7¤6 – / " gª>òÔç‡š	Î	‰
Ù
C¥Ûì�|ãw>OX³jzyŽQ\ÕVì)-b�D}£ & ¦ Û /é(CdÐÙBo¼ï
	F	e	”	
�
©Ñðûh±¼@¦£m¸xé¥_2 l ´ Ð é ¨ö@¿ìö!r@[=±Û%õ	.	'
l
í
ù
%,hB !†ž½ÉLÌ¨Ä�­â^©}  ñ¢¼âFë	P
•§ªÚX•ÅÊ0§LK	×;#Òß‡ïSN ; ™ Züa]g“£´î<a—PŽ¥Ö!	p	Ô	
#
2
V
|
¦
Ê
I)A­ïO[¤ö8(©¼ü³Àù<…‘âú¶KQ °  ;€áÝ¼òˆªÍcÓ~~¯“¨&E ,Žs - r7•ÑRÂ×"¸«Ðæ5·ó=p~•™Èã½‹šžÓ<Yµs}à'�]Ñ3!Ø l… žÓ+
p
2°2Ï†·ÏîóõûGÐÒí[) • ¯ Va	c
œaø�ò,±…¹�¢;ûŽ`qÀ‡�¼¾ÓC k 4 k ¥ ³ Ï fõ?=B qcØæ$™O
ˆ
$¤ë”{”ŸÄÉÐâ/úNW�²¼È §»:?ëèR^# :ûÁ\k³�–o	ªÏÎÒ}…Îâ7}™Ò';}’§�áì&r ¯ 0 ­ ® 89ô>[m	n	‡
ê’“ÌÍñ“žÃÈÍÎÏ.¸ùMV‘¦Ç>�Ž�ßà„…†½êB q   2|  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                          6                                                       	                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               	                                            
                                                                          	                                                                                                                                  2                                                                                  *                  	                                                                       
   "      	                     	         <   !      
   
                     	                                 $      	                                 	            2   "      ,   '      )   )      &   ©   e               -      w                                                                                                                                                                     6                         	                                                                                                                                                                                                                                                                     	                  
                          	                                                2                            *      	                         
 "  	       	   < !  
 
       	           $  	           	    2 "  , '  ) )  & © e     -  w   †ï  ˆi  ˆ“  ˆÑ  �÷  ”[  ›Û0
A§•,	k l…£a¸Öêëb•ø=™¤ö{žÐÑð7}Äßÿ£Qc	 ¹á’_š
GŸ|Ï	DÿÜ¤ À	kÚÂN“” U»0Pî‘gg	G®þ!il…£a ” .U²Ê»ÄÀ‰§x`	ln¼õtîòNª¶1þACmˆ¦!iœëñé=TßåZ~­º;g»þp¬0ª�
Ä•	V5Üäá	Y
¤¹˜Üäá	Y
¤Â¹Üäá	Y
¤¹ä¤˜ä¤U©z€©¶U¼O\×xôH?×ŒFÛ2^ó2
^àóÑ	ZCL^ à:
Ttj ‚»2V !	!ÆU'Kû=_	˜ Uœ7ÚRW+Ë$e{â`¢»`¢	–S#¹ î Aû8kT MÄËW y u~
\š{
û¿�’œ’Bï÷AŠ†[�‘ü Ÿì4
ê
šHÏê Bµ ½ÏtØ ¦u%P5¬ÆÑh¹ î Aû8k÷·ÖT ‰S* ¹A? ¤t˜š”{e#{Y{{Y¼3;™F Ü[–iÝ&|<µ™{¾{Yìê
Hžt˜™æaÈš	HîV÷UÁ&n‰Š*Èõ	 ã=
Y»fˆ
ë²ë0Â!y9)J	¯
y�÷Ã5e ’žÊîÓB_	×è™(x¥Úï
R÷A_†Šèä2 ÈÑÀ
-Ò±q
«Æ*-×š’&¨¿\ÝŽä8P¼”	�
,Û…Ú"Bž{|âãNÉì&;›¨<á5 	’u!¢áÚôö¢ª
ª¯7ì	s…'‡U0š=æWðqšê’-Â}¨¿,BÉ¨ ¢t˜µš”™{æ¾e#a{Yõê ¹AMÄ¨¿Ý¼”	�
,BÉ&¨D¸ÇÓz7U'” U|š<O¬`	Ø
Ü
à
ä
è
såî÷J£ª�°èþv„¯&[nŒF!ci…‰²¶ì	p�úPu¥,Ñ ¨¿Ž8,Ú"BžÉ¨¹å	&n‰A’ž¸9ÁÐ	MÜT£™#ÂÍ#//@e  ­�\ç"nõ
Gã,Žlc;žƒ6IýÞù:™®¸Ã‰Wt˜ŸÈÑ¦À
u%-PÒ5¬ÆÑh¯YÙª»	ü¥Mµ(p). ˜ËW y Œ. YÖM˜\é	˜
{J[ÄË{cYW y  ÇuÓàíõê¤ 	Ó	:
U
¿
ü
T£²\	EN¡Ù_€¢Ç}*°tÇ ` j wú * ÿ·ÙD» ª¯ì	ùŽž`�•Š7ãë¿9
¼30)`�ËW y ‰S¼q
3«±Æ*àAÀ	«Ãô —\v„é$ö „¢ò‡iŠ½œƒ lz¨
Y´YWžÁÜTl£™#Â#/] Ÿ¹ß:Ñ	 
@NòxÎ0 An ™ Za£aPÖ	2
¦
ÛA[ö|ã>Oz<\ÕâíKþ}~`Ít×š` /9É’¤&	i	º	ÂûûG§ìbÐ5_ˆåhN‘âô—ØÛ©ñ_ “ T�ë^`„Ð	_	è™š_ƒ’èx¦àüè7H&¼;<û›¼tÓ¬Ù`Ú˜‰+	²)z�ë^„Ð	’xüH&9É’Âìb5_hNØÛ©_ /¤&	i	º	ûûG§Ðˆå‘âô—ñr@[±%	'
l
í
ù
%!žÌÄâ^}GN¥¾®	á	„0	ïÜ7í’'X6
wÞ /9ƒÉ’¤&	i	º	ÂþûëûG §³êìû>LbñœÐÛ5:_ˆßâåÑ1ZhÜN‘âô÷m—ØÛ©ñD_¾£• ™ Za£aPÖ	2
¦
ÛA¼[ö|ã>O;<û›z<\Õâ¼tÓŽîÎ*rZmm™µm¯—WàØ×¯‡’ ;ÐÎ—l»„Ôá•gª‡‰
Cì³yVìb�D£ J¸ã– ¤Óià	”
<f/Hïsd²(
L
m
î
ÏŸª_~A�,
ÐTí“€ ^ï."	@	Jþ�¯Æ á x ¾i�•;a
…
{yK‹Š K]þ+f,Ú’70ræRÈb8qtA^ï.+Ž�"	@	,
JÐþ�Tí“¯€ Æ !«,g-ÛD�öeï„íHã,~–sŽlÙÓàcE'‹·§é¿×• ¯ Va	ø�ò,±…�¢q0goOz“ªÚÐ³
�	1v<	Š	Ä	õ
´Ë_×H^Ýc—ÓøœÝ(´¹| !RôNj�Ÿ¶Ê¦ÀÇV Y œ[™¨¶ÈB7ž?	L	-
�ÈH„ÑÚÝýRWÕ-Žõ±ÿ`æm+6®� Ñ×¸«Ðp~•™Èšs}à']!2é%Ý~34˜~ Õ 2aû L£	ƒ[gq£[¦åYt¿ù’Nùz°2»U7aNilU'Ë!EÚÝF4¹Â¹•‹4È&gÔ
	<	Ä	´×H´Úv^—Ý¹| aƒgq£¿’Ð³�1Š	õ
Ë_ÝcÓøœ(!ƒþë ³êû>LñœÛ:ßâÑ1ZÜ÷mD¾£• «,g-Ûã,D�öe~–sŽlÙÓàï„íHcLºJìþ$æšB!d H	ü	(fß¨×›½[ �ð
P!€ + { tfŸ¾.n³3K_×9f†£§©o´þë7 Ð z – ¢ ° W;µb	ìùž½ëó-²k†Žš£¯¹Äò�ÜÒÿA[ÚÝrÌnŠ	•ŠýXEê7¤6 – ²ÓPƒ0þßg� ³oû>LO:zßâú1“ª´÷þ“¾  3j‹¾[“Ø[)�„ u�™†;?ÀRéNw€%	h	…	B
Ä
ç
Ää³4ÀÁ7Aa+PÕÛñP�èpqzÞß  †

lsue/4AJ`z‚ðø8]g…‡kg¨Äåó6šHµ>›ì8 Ï @ }¥Þ½=‰TÎõd#'—Ó×0-|Ÿ¹ßäó:ÂÑ	 
>
@NXÝUZm¤òCLš$xÃÎÖ$0™î .0Ae^ f n   “ T¨aí	D	_	
5
ë
è0š_ƒ¢µé§à­êð$›IÐë¡OZlè8Cv
¼«"°<™æü›õ8í
'£½{1tâÔm©À÷öu¡ºI€ë±/	æ	-iC'oÊwÐŠ©Ã)½èBýUy  !  i “ œ Tu{�™ÃÌê@†ôW¿ð.;?ƒÀÕ ,R¨éNm”£¯aw€Ùíó	%	D	_	h	…	˜	¹	
5
B
v
©
¹
Ä
ç
ë
*f»Ääè0š$_³4Fƒ¢­µé€§àçî²À­Á
RÍêð$*7A›¬´Ïè<EIa‡Óä÷6bl}Ðëï+;ñPÕÛñ%:P�¡óOZl†èpuŽÝ)TqÜè+/8zÔÞC¡ ß ï ' f m o q ‚ É Ñ )+bmu©jlÀ÷Nöu¡ºÅ>I€ë ±Í/	æ	-i—-‘Ýð!:RC3h	—'fo‡ÊâGw·ÐéŠ©Ãå)T½Åèî.B‚ËüZ\^®ÑýU[hy»òÏ  u ™  !º Æ ï B“üro9lyó©BNl'  U R�È1«ã
| )hqä0‹*ÙçM‘“|¤óMfZþ S ¶Oxþ¡€¾ÐÛß1yÕu^:lkÙ û l… žÓ+
p
2°2Ï†·ÏîóõûGÐÒí[)d$^JþŒ'*{³¡Ñæ@gB	 	1:û6K‡Š—Uèî"jª2—±´øˆÙ¿ G „ŠTq~ØFU·ÈÓÝ\—7<Jj‘þž Ü º Æ ï Bq“üeu�™Øà_†ÐKQ;?ŸÀR|é	N`iÌçAJOrw€·Ò%	h	…	¡	1
B
{
Ä
É
ç
2Ää(¯o¬³49Zly”ó©ÀòBNÁ@7A’al´û'+¿ëPÏÕÛñP„�µèNapù\q +�z ÞP U À ß Hm½�	ü
T4¥�õiAãÑÌ¥IX z    -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  *š<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8077" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7286-8077" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8078-8146" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4985-5779" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="2" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3243-3831" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6527-7115" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4147-4575" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="50-429" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4589-4918" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="430-633" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4769-4904" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5955-6076" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8147-8251" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="3xMyc" directionality="1" translationMW="3573.98" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3222" maxFusedRunOn="3222" detectionMode="exactProteinMatch"><Segment range="3130-3219" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;3 tandem Myc epitope tags&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="EQKLISEEDLEQKLISEEDLEQKLISEEDL"/></Q></Feature><Feature recentID="12" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3897-3945" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="6173-6179" color="#ffffff" type="standard"/><Segment range="6180-6197" color="#ffffff" type="standard"/><Segment name="-35" range="6198-6203" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6218-6239" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6125-6141" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6149-6165" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3713" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="3330" maxFusedRunOn="3330" detectionMode="exactProteinMatch"><Segment range="3714-3725" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="700-709" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="19" name="VCP" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3222" maxFusedRunOn="3222"><Segment range="706-3123" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGSVYTEDNDDDLYG"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  Ì<Notes>
<UUID>5bc41cbb-595a-4d37-b20a-0169107753ec</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-VCP(human)-3Ã—Myc-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:57:5">2022.12.27</Created>
<LastModified UTC="19:42:16">2025.9.20</LastModified>
<CreatedBy>Triple Threat</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d               E              ÿÿÿÿYô? P                                                                                                                                                              «<StrandColors><TopStrand><ColorRange range="699..704" colors="green"/></TopStrand><BottomStrand><ColorRange range="699..704" colors="green"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
